Anonymous #1 4d

I disagree with this, and primarily because it only fixes 1 issue without addressing the underlying fat concerns. Why do people get fat? Because they eat too much food, usually due to their diets being made up of calorie dense, low satiating foods, and they don’t exercise enough. GLP-1s do not address either of these core issues. It leads to people who STILL eat like shit and don’t exercise, they just eat less so they aren’t fat, but are typically still wildly unhealthy.

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Anonymous OP 4d

Giving people an avenue for weight loss that does not address these underlying issues allows them to ignore the underlying issues, rather than being forced to address them to lose the weight. Compare that to weight loss without drugs, which almost unfailingly, DOES demand these positive lifestyle changes (at least if you want the weight to stay off). GLP-1s are a resource to be utilized, but for 99%, the underlying lifestyle issues must be addressed before introducing GLP-1s

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Anonymous OP 4d

Yeah, I wish people would eat healthier too, and make all sorts of lifestyle changes but many clearly can’t do it. At least with the GLP-1 medication, they’ll eat less and they’ll lose weight and many of the metabolic issues that come with being fat (joint pain, reduced mobility, high cholesterol, cardiovascular problems, lower QOL, etc.) will diminish Of course, a GLP-1 won’t make anyone exercise, but if they’re losing weight regardless, it’s a step in the right direction.

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Anonymous #1 4d

“Can’t” is a very dismissive word, when most have never had a truly serious attempt where they were educated on proper weightloss methodology, and actually stuck to it for more than a week. I’m speaking as a coach who has successfully induced drastic fat loss for dozens of clients, and it almost always comes down to proper guidance, and accountability. Injecting exogenous chemicals should be a last resort, not the standard.

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Anonymous OP 4d

If someone has PCOS and is insulin resistant then it’s not JUST eating healthy. I’m not going to write a book on here because Google is free, but do literally the bare minimum of research instead of spouting bs. Some people’s bodies literally make it WAY harder for them to lose weight and it has nothing to do with just eating less.

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Anonymous #2 4d

“Nothing to do with just eating less” If you can’t comprehend the basic physics that make this statement absolutely ridiculous, then you’re honestly just a lost cause Also, I’m not sure you understand what insulin does if you think it makes someone incapable of losing weight. Does it make it harder? Yes. Does it change the equation? No.

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Anonymous #2 4d

“Bare minimum amount of research” I have a degree in kinesiology with a minor in nutrition and am a practicing fitness coach while I just finished my 3rd semester of PT school. In the most respectful way possible, I know what I am talking about, and you do not.

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Anonymous OP 4d

Agree for most people but I can down 4k+ calories of highly satiating whole foods every day without any trouble (quite literally what I’m doing rn in a bulk) so it’s definitely beneficial for suppressing appetite in people who already know how to optimize their diet and exercise

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Anonymous #3 4d

Yes this is an instance where it is a useful tool for someone who already has their other variables taken care of, and is using it as a tool alongside those habits. It’s only a problem when people are using it to bypass the steps of healthy eating and exercise, which is the majority of people who are on them.

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Anonymous OP 4d

You have no idea what you’re talking about. If you do, please explain the effect insulin resistance has on weight gain, its effect when trying to lose weight, and how those issues can be solved just as easily with a caloric deficit WITHOUT a GLP-1. Literally all research will tell you that it is SIGNIFICANTLY more difficult to lose weight in that situation. But you do seem like the type to ignore blatant facts so tbh idc. Spew more bs, it’s not bothering me.

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Anonymous OP 4d

Oh & while you’re at it, find a resource where it’s just as easy for insulin resistant ppl to lose weight as those that have no insulin issues. Then copy & paste the paper here. 🤣🤣🤭 lmfao

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Anonymous #2 4d

Insulin resistance, as the name suggests, is your body’s ineffectiveness at responding to insulin, which is primarily responsible for pulling blood glucose out of the blood stream to be utilized and stored, primarily in the form of glycogen. What this resistance does is cause the pancreas to release insulin for longer periods of time, as the body doesn’t stop releasing the hormone if blood glucose is still elevated.

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Anonymous OP 4d

This results in higher levels of insulin tie bloodstream for longer periods of time. The common misconception here is that this causes the blood glucose to be stored as fat, rather than as glycogen, but this is a common misconception, given that mechanistically, a surplus of fat storage requires a calorie surplus, as energy must come from somewhere (you cannot mechanistically add more adipose tissue if you’re in a deficit, it is not possible).

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Anonymous OP 4d

Another common misconception is that insulin resistance causes a decrease in caloric expenditure at the BMR level, but it just… doesn’t, and there is no mechanism to suggest why it would. Insulin resistance isn’t slowing down your metabolism. People will also claim it can lead to increased hunger, but again, there’s nothing to support this.

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Anonymous OP 4d

How CAN insulin resistance lead to weight gain? Through indirect lowering of physical activity. Glucose is the body’s primary energy source, and a lack of an ability to store glucose as glycogen leads to overall lower energy stores available, and typically, makes the person less likely to be moving throughout the day.

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Anonymous OP 4d

Does this make it MORE difficult to lose weight? Yes, as it makes exercising more difficult to stay consistent with. Can someone with insulin resistance still lose a lot of weight if they work hard? Yes. Does it change the biological mechanisms by which weight loss occurs so that it has “nothing to do with just eating less?” No.

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Anonymous #2 4d

And for the study, I’d like to refer you to PMID: 26278052 This compares fat loss in 2 groups, 1 with a diet of moderate carbs and low fats, and the other with low carbs and moderate fats. The moderate carb group saw a significantly higher decrease in fat mass, despite these subjects having a greater insulin response (since insulin responds to glucose). This mechanistically shows that increased insulin levels do not lead to fat retention.

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Anonymous OP 4d

Any other questions, or does that cover it?

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Anonymous #4 4d

And in a few years I’m sure there will be another shiny new toy that every 19 year old wants to hop on. Everyone wants a quick fix, but short of anabolics, those simply do not exist.

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Anonymous #2 4d

Also, I’d like to point out that you seem to have a fundamental misunderstanding of the burden of proof? YOU are making the claim against that insulin resistance makes fat loss difficult to the degree that it “has nothing to do just eating less,” and instead of providing any sort of evidence or even line of reasoning, demand for me to disprove your claims, despite those claims having absolutely 0 substance provided.

4

Anonymous OP 4d

It would be like me saying “you robbed me. I have 0 evidence that you robbed me, and I cannot identify any reason that you would rob me, but instead of me proving that you robbed me, you have to prove that you didn’t rob me.” I’m not sure if you’re familiar with the judicial system, but that isn’t typically how the burden of proof works.

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Anonymous OP 4d

So now I’ll ask you, can you please explain to me the mechanism by which insulin resistance would cause an individual to be unable to decrease their body mass, despite being in a caloric deficit? I cannot wait for your incredibly intelligent reply! After all, I am but a humble grad student who’s whole career and field of study revolve around this subject matter and its application, while you, oh wise one, have Google!

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Anonymous OP 4d

Wrong info & your misquoting me 😴 why am I not surprised 😂

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Anonymous #2 4d

Lazy ragebait, and also just a shitty place to be ragebaiting dude. People here are asking for help genuinely. Go be a loser somewhere else

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Anonymous OP 4d

Of the two of us I’m certainly not the loser.

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